Myxedema in patient of hypothyroidism
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The clinical features of hypothyroidism are variable, many a times nonspecific. |
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A high index of suspicion is necessary especially in patients who are at risk for developing hypothyroidism but still are subtle in their presentation. |
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The clinical features vary with age of onset and severity of hypothyroidism |
Clinical manifestations of hypothyroidism in general / in adults.
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Fatigue |
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Lethargy |
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Mental impairment |
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Depression |
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Goiter |
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Non-pitting Edema (swelling of body, limbs which does not pit on pressure) |
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Menstrual abnormalities in women |
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Cold intolerance |
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Hoarseness of voice |
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Repeated abortions in productive age of women. |
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Dry skin |
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Weight gain |
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Arthralgias (pain joints) |
Hypothyroidism during adolescence
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Delayed puberty |
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Growth retardation with delayed bone age |
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Galactorrhoea (secretion of milk at nipple) |
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Menstrual disorders in adolescent girls |
Hypothyroidism during childhood
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| Dry skin, generalized myxedema |
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| Constipation |
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| Delayed dentition (eruption of teeth) |
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| Growth retardation (failure to grow) |
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| Delayed skeletal maturation (bone growth) |
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| Myopathy (muscle weakness) |
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| Precocious sexual development (abnormal sexual development) |
Clinical manifestations of congenital hypothyroidism
Early neonatal hypothyroidism
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Prolonged icterus (jaundice at birth) |
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Edema (swelling of body ) |
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Birth weight > 4 kg |
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Post datism : gestation > 42 weeks |
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Poor feeding, hypothermia (decreased body temperature) |
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Abdominal distension |
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Large posterior fontanelle (soft area in skull of new born) |
Onset during lst month
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| Peripheral cyanosis / mottling (blueness of body) |
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| Respiratory distress (breathing difficulty) |
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| Failure to gain weight |
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| Constipation |
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| Decreased activity |
Onset during first 3 months
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| Umbilical hernia (protrusion of abdomen at navel) |
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| Constipation |
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| Hoarse cry |
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| Macroglossia (large tongue) |
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| Generalized myxedema (swelling of body) |
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| Dry skin |